When designing a new wet granulation process, you must consider many different options — a difficult task since much of wet granulation is still a trial-and-error process. However, you can make educated design choices that will help achieve final granules with the properties you need.
Probably the two most pressing decisions in designing a wet granulation process are selecting feed material (that is, the powders and binders you’re going to use) and choosing granulation equipment. You may have little material selection flexibility, because often you need to granulate the powders you have available. But if you can choose various qualities for some of your powder and liquid binder ingredients, you’ll find it easier to achieve the result you’re looking for.