Columnist Rachel Smith details three common simultaneous mechanisms, also known as rate processes, that occur during granulation and the problems they can cause.
Granulation is difficult to predict for several reasons. Powders behave as discrete entities — unlike fluids, which behave as a continuum — and can be hard to model. This column looks at nucleation, consolidation and growth, and breakage, mechanisms that often compete with each other, and at how changing a single aspect of your granulation process can affect one, two, or all three of these mechanisms.